KOPESTER DO: PHARMA

Topical medication is one of the most important and crucial medication in healthcare industry. Global Topical Drug Delivery Market is expected to Reach USD 194.2 Billion by 2024, at a CAGR 9.3% during the Forecast Period of 2017 to 2024. Topical formulations for pharmaceutical delivery are becoming increasingly popular. Topical delivery has a number of advantages: the ability to deliver drug substance more selectively to a specific site, avoiding fluctuations in drug levels, inter- and intra-patient variations, improved compliance, and an enhanced suitability for self-medication. Skin provides an ideal site for the delivery of drug substances for both local and systemic effects. However, it also acts as a mechanical barrier to the penetration of many drug substances. The advantages of topical therapies rely on having the right formulation. A small change in the formulation can make a large difference in the efficacy of topical treatments.

With topical therapies, the formulation is as important as the molecule itself because the interaction of the vehicle with the skin can alter the efficacy of the penetrant. The formulation ensures that the drug substance is delivered to the right target site and that it maintains dosage integrity, drug transport, and active duration.

The selection of the right excipients for topical formulations is extremely important. The drug substance may be efficacious, but its interaction with excipients may alter the following:

? Its ability to permeate through skin

? Its stability through shelf life

? Its ability to not metabolize in skin

? Its ability to stay dissolved at right concentrations

? Its capability to achieve desired release rates

One of the most preferred excipient/Penetration enhancer of topical product developers is Kumar Organic?s Kopester DO- Pharma

Kopester DO (Decyl oleate) is an emollient derived from Decanol and Oleic acid. It is an ester derived from vegetable oil (naturally) and is synthesized by biotransformation process. It is an emollient with medium spreadability. It helps to retain moisture on the skin making it excellent choice for topical formulations like creams, ointments and lotions. When it is used in topical formulation gives stable emulsions to achieve the physico-chemical characteristics required for optimal delivery of API. It has a potential to solubilize lipid and makes it a ideal choice to use with lipophilic API?s (fat soluble API). It also has lubricating, conditioning and non greasy properties, which makes the skin supple and soft when applied. It also enhances the consistency and appearance of creams and lotions. Kumar Organic?s Kopester DO complies to EP monograph.

To conclude, the type of optimal formulation is determined by the properties of the drug substance, excipients used, and target area. Great improvements can be found by considering both the properties of the skin and the properties of the drug substance and excipients used. The importance of the right formulation and delivery method in topical pharmaceuticals is critical. It can mean the success or failure of drug substance.