Zinc Pyrithione was first reported in the 1930s. It has two pyridine-derived chelating ligands bound to zinc via oxygen and sulfur atoms. In cosmetics and personal care products, Zinc Pyrithione functions as an antidandruff agent, antimicrobial agent, hair conditioning agent, and preservative. Zinc pyrithione has been used, as an anti-dandruff agent, for more than 60 years, in concentrations up to 1-2%. It is effective against a wide variety of pathogenic bacteria. Its other applications include treatments of psoriasis, eczema, ringworm, fungus, athletes foot, dry skin, and atypical dermatitis.

Due to its low solubility in water, zinc pyrithione is suitable for use in outdoor paints and other products that provide protection against mildew and algae. Its decomposition by ultraviolet light is slow, providing years of protection even against direct sunlight.Antifungal effect of Zinc prithione is most likely lies in the ability of an un-ionized pyrithione molecule to disrupt membrane transport by blocking the proton pump that energizes the transport mechanism.

Bis-[1-hydroxyl-2(1H)-pyridinethianato-O-S]-zinc

Zinc Pyrithione 50% FPS

Zinc Pyrithione Powder

Regulation:
USA: Approved for OTC topical use
Europe: Approved for OTC topical use
Japan: Approved for OTC topical use
Rest of the World: Approved for use in many Asian, African and South American countries.

Consult your regulatory authority for use level and restrictions.

Selected Safety Data:
In classical toxicological terms, Triclosan is relatively non-toxic to humans and other animals. The acute as well as the subchronic toxicity was moderate to low, for both Zinc Pyrithione alone, or incorporated in market formulations. In chronic toxicity experiments it was shown that an oral application of 500 μg/kg/day can be regarded as a dose that does not cause any adverse effects (NOAEL). No evidence of a carcinogenic response was seen when Zinc Pyrithione was applied topically up to 100 mg/kg/day or given orally up to 5 mg/kg/day in lifetime studies.

Packaging Sizes :
For Dispersion : 25 Kg drums
For Powder : 25 Kg HDPE with double polyliners or 20 Kg net paper bag with inner bags
Shelf Life : Minimum 5 years
Storage Conditions : Keep away from sunlight and heat

Literature References:
[1] G Lorette, and V Ermosilla, Clinical efficacy of a new ciclopiroxolamine/zinc pyrithione shampoo in scalp seborrheic dermatitis treatment, Eur J Dermatol, 16(5):558-564, 2006.
[2] E Guthery, LA Seal, and EL Anderson, Zinc Pyrithione in alcohol-based products for skin antisepsis: Persistence of antimicrobial effects, Am J Infect Control, 33(1):15-22, 2005.
[3] KS Grunnet, and I Dahllof, Environmental fate of the antifouling compound zinc pyrithione in seawater, Environ Toxicol Chem, 24(12):3001-3006, 2005.
[4] P Bailey, C Arrowsmith, K Darling, J Dexter, J Eklund, A Lane, C Little, B Murray, A Scott, A Williams, and D Wilson, A double-blind randomized vehicle-controlled clinical trial investigating the effect of ZnPTO dose on the scalp vs. antidandruff efficacy and antimycotic activity. Int J Cosmet Sci, 25(4):183-188, 2003.
[5] RS Berger, JL Fu JL, KA Smiles, CB Turner, BM Schnell, KM Werchowski, KM Lammers, The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial, Br J Dermatol, 149(2):354-362, 2003.

The information given and the recommendations made herein are based on our research and literature search and are believed to be accurate but no guarantee of their accuracy is made. This information is intended to be helpful, but no warranty is expressed or implied as to the results obtained from use in the formulation, procedure or products suggested herein. Neither is any permission or recommendation to practice any invention covered by patent either expressed or implied.

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