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Sodium Pyrithione

Sodium pyrithione inhibits growth of fungi, yeast, mold and bacteria. Sodium and zinc salt of pyrithione N-oxide are widely used in cosmetics and shampoo. In acidic media, amine N-oxides are cationic and can act as a mild conditioner. They are used in body care products. Pyridinethione derivatives, belong to a class of cyclic sulfur organo products containing sulfur atom (S) and often oxygen (O), nitrogen (N), hydrogen (H), as well as other elements, can find application for making biologically active agents such as antiviral, antibacterial, antifungal agents.

Molecular Formula : C4H4NNaOS
CAS # : 3811-73-2
EINECS : 223-296-5
Molecular Weight : 149.16

Physico – Chemical Properties:

Appearance Dark yellow to amber brown solution
Solubility Freely soluble in water
pH (neat) 8.5 to 10.5
Refractive index 1.477 to 1.487
Assay 40 to 42%

Application:
It is used in formulating anti microbial property for Aerosol, Paints, Shampoo, Sealants, Adhesive, Textiles, Plastics & Floorings.

Regulation:
1. Registered by the US EPA under the Federal Insectiside, Fungiside, and rodenticide Act.
2. Registered in Europe under the Biocidal Products Directive.
3. Approved for use in many Asian, African & South American countries. Consult your regulatory authority for restriction and use level.

Packaging Sizes : 25 Kg HDPE drums
Shelf Life : Minimum 2 years
Storage Conditions : Store in cool dry well ventilated place.


Literature References:
[1] Topical and Systemic Absorption of Sodium Pyrithione following Topical Application to the Nails of the Rhesus MonkeyPhilip R. Mayer, Ronald C. Couch, Mary K. Erickson, Bradley Wooldridge, R.K. Brazzell Research and Development, Alcon Laboratories, Fort Worth, Tex.; Primate Research Institute, New Mexico State University, Holloman Air Force Base, N. Mex„ USA.
[2] Synergistic Wood Preservatives: Terrestrial Microcosms (TMCs) and Field Exposure Efficacy Studies of the Synergistic Copper: Pyrithione Mixture; wood and fiber science; Tor P. Schultz, Professor, Thomas Nilsson, Professor, Darrel D. Nicholas, Professor.
[3] A novel assay for the distribution of pyrithione biocides in bacterial cells: Dinning, AL-Adham, Austin & Collier School of Molecular and Life Sciences, University of Abertay Dundee, Dundee, Faculty of Pharmacy, Jordan University for Women, Amman, Jordan, Zeneca Specialties, Blackley, Manchester, UK

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