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Kopdil
Minoxidil was first used exclusively as an oral drug to treat high blood pressure.It was found to have the interesting side-effect of hair growth and reversing baldness.Since 1988,Minoxidil has been used for treating hai loss.The mechanism of action for Minoxidil is not known,as no oyher vasodilator has been shown to be effective in treating hair loss.Recently, researchers at L'Oreal Suggested that Minoxidil works by activating PGHS 1 (prostaglandin endoperoxide synthase-1) which may help promote hair growth.Hair disorders cause psychological distress but are generally poorly controlled.Minoxidil is very effective in frontal area in male-pattern hair loss. Typical use level is from 2 to 5% in solution. Minoxidil is the only proven hair loss treatment available without prescription.
2,4-Diamino-6-piperidinopyrimidine-3-oxide
Physico – Chemical Properties:
Regulation:
USA: OTC drug
Europe: Annex II, Approved for use as an OTC drug
Japan:Quasi-Drug
Rest of the World: Approved for use in Mexico, many Asian, South American and African countries
Consult your regulatory authority for use level and restrictions.
Selected Safety Data:
As as drug to combat hair loss,the most common side effect is itchy scalp. Alcohol present in topical preparations may dry the scalp,resulting in dandruff. In some cases Minoxidil may initially cause an increase in hair loss. This is called shedding and is seen as a long-term positive effect during hair loss treatment since the shedded hair strands will re-grow within a few month with renewed strength.There have been cases of allergic reactions to Minoxidil or the non-active ingredient propylene glycol,which is found in some forma of topical Minoxidil. Large amounts of Minoxidil can cause too much of the drug absorption by the scalp,as can using the drug on sunburned scalps.If a person uses Minoxidil to stop hair loss for a length of time and then stops taking the drug, hair loss will occur again. Minoxidil is highly toxic to cats and can cause death when applied to their skin.
Packaging Sizes : 25 Kg HDPE drums
Shelf Life : Minimum 2 years
Storage Conditions : Store in original, sealed container, avoid light and heat.
| Molecular Formula | C9H15N5O |
| CAS # | 38304-91-5 |
| Molar Mass | 209.25 |
| EINECS | 253 – 874 – 2 |
| Appearance | White to off-white crystalline powder |
| Assay for minoxidil(on dried basis | 97 – 103 % (w/w) |
| Heavy metals | 0.002% max |
| Total Impurities | Not more than 1.5% |
| Solubility |
Soluble in ethanol ( ̴2%) & propylene glycol ( ̴7%), Sparingly soluble in methanol, slightly soluble in water. |
USA: OTC drug
Europe: Annex II, Approved for use as an OTC drug
Japan:Quasi-Drug
Rest of the World: Approved for use in Mexico, many Asian, South American and African countries
Consult your regulatory authority for use level and restrictions.
Selected Safety Data:
As as drug to combat hair loss,the most common side effect is itchy scalp. Alcohol present in topical preparations may dry the scalp,resulting in dandruff. In some cases Minoxidil may initially cause an increase in hair loss. This is called shedding and is seen as a long-term positive effect during hair loss treatment since the shedded hair strands will re-grow within a few month with renewed strength.There have been cases of allergic reactions to Minoxidil or the non-active ingredient propylene glycol,which is found in some forma of topical Minoxidil. Large amounts of Minoxidil can cause too much of the drug absorption by the scalp,as can using the drug on sunburned scalps.If a person uses Minoxidil to stop hair loss for a length of time and then stops taking the drug, hair loss will occur again. Minoxidil is highly toxic to cats and can cause death when applied to their skin.
Packaging Sizes : 25 Kg HDPE drums
Shelf Life : Minimum 2 years
Storage Conditions : Store in original, sealed container, avoid light and heat.
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